Main block and flanking wings at Royal Berkshire Hospital

The main block and flanking wings at Royal Berkshire Hospital were built in 1839 by local architect and builder Henry Briant, who won the design competition for the hospital. Notably, the central pediment features the Arms of King William IV, reflecting his keen interest in the hospital's establishment, rather than those of Queen Victoria. The building is two storeys tall with a basement, constructed from very large ashlar blocks of Bath stone and topped with slate roofs. It has eleven bays, with a central seven-bay section that projects and features a pedimented hexastyle Ionic portico. The windows are glazing bar sash, and there are corner piers, a channelled basement, and a moulded cornice with an astragal, as well as a dentil cornice on the portico and a parapet. The portico is accessed by wide steps, which are adorned with excellent contemporary lamp tripods featuring guilloche ornament.

Inside, there is a colonaded stair hall with cast iron balusters on the stairs that divide at the landing. An 1882 chapel with contemporary fittings is accessible from beneath the landing, designed by Joseph Morris, who made significant extensions to the hospital at that time. The main block has flanking wings added in 1865, also designed by Joseph Morris, which are three storeys high and constructed from Bath stone. These wings form a large courtyard and were completed between 1881 and 1882. They feature end pavilions with five bays and pedimented breaks, linked to the side wings by a Greek Doric colonnade on the east side, and a block added in 1911 on the west side. In front of the building, there is a dwarf stone wall with moulded coping and five retaining ashlar gate piers topped with block modillions.